abstract：:Massive pulmonary emboli is a rare disease in children, with only 39 reported cases in the last 50 years. Almost 50% of the patients died suddenly without receiving medical treatment. Most of the patients who were managed medically (70% of the treated patients) underwent surgical pulmonary embolectomy with 80% surviva...

journal_title：Chest

authors： Eini ZM,Houri S,Cohen I,Sion R,Tamir A,Sasson L,Mandelberg A

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Small cell lung carcinoma (SCLC) continues to have a poor prognosis, with a 2-year survival of < 20%. Studies have suggested that SCLC may affect the immune system to allow it to evade immunologic responses. We hypothesized that any such effect would be characterized by a decrease in the lymphoid cells assoc...

journal_title：Chest

authors： Wang W,Hodkinson P,McLaren F,Mackean MJ,Williams L,Howie SEM,Wallace WAH,Sethi T

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Asthma is a worldwide problem. It cannot be prevented or cured, but it is possible, at least in principle, to control asthma with modern management. Control usually is assessed by history of symptoms, physical examination, and measurement of lung function. A practical problem is that these measures of contro...

journal_title：Chest

authors： Green RJ,Klein M,Becker P,Halkas A,Lewis H,Kitchin O,Moodley T,Masekela R

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:D6 is an atypical chemokine receptor involved in chemokine degradation and resolution of acute inflammatory responses in mice. Emerging evidence suggests that D6 might behave differently in human chronic inflammatory conditions. We, therefore, investigated the involvement of D6 in the immune responses in COP...

journal_title：Chest

authors： Bazzan E,Saetta M,Turato G,Borroni EM,Cancellieri C,Baraldo S,Savino B,Calabrese F,Ballarin A,Balestro E,Mantovani A,Cosio MG,Bonecchi R,Locati M

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Approximately 40% of patients in medical ICUs require mechanical ventilation (MV). Approximately 20% to 25% of these patients will encounter difficulties in discontinuing MV. Multiple studies have suggested that MV has an unloading effect on the respiratory muscles that leads to diaphragmatic atrophy and dys...

journal_title：Chest

authors： Grosu HB,Lee YI,Lee J,Eden E,Eikermann M,Rose KM

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Identification of sleep-disordered breathing (SDB) using questionnaires is critical from a clinical and research perspective. However, which questions to use and how well such questionnaires perform has thus far been fraught with substantial uncertainty. We aimed at delineating the usefulness of a set of que...

journal_title：Chest

authors： Spruyt K,Gozal D

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Infused and inhaled treprostinil are effective for treatment of pulmonary arterial hypertension (PAH), although their administration routes have limitations. This study assessed the efficacy and safety of bid oral sustained-release treprostinil in the treatment of PAH with a concomitant endothelin receptor a...

journal_title：Chest

authors： Tapson VF,Torres F,Kermeen F,Keogh AM,Allen RP,Frantz RP,Badesch DB,Frost AE,Shapiro SM,Laliberte K,Sigman J,Arneson C,Galiè N

更新日期：2012-12-01 00:00:00

abstract：:Over the past 10 years, significant strides have been made in the understanding, development, and availability of sleep disorder therapeutics. In this review series, we discuss the current evidence surrounding the mechanisms of actions, indications, efficacy, and adverse side effects associated with the available arma...

journal_title：Chest

authors： Gulyani S,Salas RE,Gamaldo CE

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:COPD has been described as a risk factor for excessive expiratory tracheal collapse, but its prevalence and clinical correlates have not been fully determined. The purpose of this study is to prospectively determine the prevalence of excessive expiratory tracheal collapse among patients with COPD and to test...

journal_title：Chest

authors： Boiselle PM,Michaud G,Roberts DH,Loring SH,Womble HM,Millett ME,O'Donnell CR

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Whether proadrenomedullin (ProADM) improves the performance of the Risk of Early Admission to ICU (REA-ICU) score in predicting early, severe community-acquired pneumonia (ESCAP) has not been demonstrated. METHODS:Secondary analysis was completed of the original data from 877 consecutive patients with commu...

journal_title：Chest

authors： Renaud B,Schuetz P,Claessens YE,Labarère J,Albrich W,Mueller B

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:International guidelines advocate a standard approach to asthma management for all, despite its heterogeneity. "Personalized" treatment of inflammatory asthma phenotypes confers superior benefits. We wished to evaluate dose response to inhaled corticosteroids (ICSs) in patients with asthma with an elevated f...

journal_title：Chest

authors： Anderson WJ,Short PM,Williamson PA,Lipworth BJ

更新日期：2012-12-01 00:00:00

abstract：:Immunohistochemistry has come to occupy a key position among the armamentarium of tools pathologists apply to the evaluation of lung and pleural neoplasms. This technique uses antibodies that bind to specific antigens, usually proteins, enabling microscopic detection of the antigens. Over the last several decades, an ...

journal_title：Chest

authors： Mani H,Zander DS

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVES:Immunosuppressive pharmacologic agents prescribed to patients with diffuse interstitial and inflammatory lung disease and lung transplant recipients are associated with potential risks for adverse reactions. Strategies for minimizing such risks include administering these drugs according to established, safe...

journal_title：Chest

authors： Baughman RP,Meyer KC,Nathanson I,Angel L,Bhorade SM,Chan KM,Culver D,Harrod CG,Hayney MS,Highland KB,Limper AH,Patrick H,Strange C,Whelan T

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Pulmonary hypertension (PH) is a well-recognized complication of COPD. The impact of PH on exercise tolerance is largely unknown. We evaluated and compared the circulatory and ventilatory profiles during exercise in patients with COPD without PH, with moderate PH, and with severe PH. METHODS:Forty-seven pat...

journal_title：Chest

authors： Boerrigter BG,Bogaard HJ,Trip P,Groepenhoff H,Rietema H,Holverda S,Boonstra A,Postmus PE,Westerhof N,Vonk-Noordegraaf A

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Precapillary pulmonary hypertension (PH) is a complication of pulmonary Langerhans cell histiocytosis (PLCH) associated with increased mortality. However, outcomes and efficacy of pulmonary arterial hypertension (PAH) therapies in patients with PH complicating PLCH(PLCH-PH) remain unknown. METHODS:Consecuti...

journal_title：Chest

authors： Le Pavec J,Lorillon G,Jaïs X,Tcherakian C,Feuillet S,Dorfmüller P,Simonneau G,Humbert M,Tazi A

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Although marital status has been shown to affect the outcomes of many conditions, there are limited data on the relationships between marital status and the presentation and outcomes of pneumonia. METHODS:We used Veterans Affairs administrative databases to identify a retrospective cohort of male veterans a...

journal_title：Chest

authors： Metersky ML,Fine MJ,Mortensen EM

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:The aim of this prospective, multicenter study was to define the accuracy of lung ultrasound (LUS) in the diagnosis of community-acquired pneumonia (CAP). METHODS:Three hundred sixty-two patients with suspected CAP were enrolled in 14 European centers. At baseline, history, clinical examination, laboratory ...

journal_title：Chest

authors： Reissig A,Copetti R,Mathis G,Mempel C,Schuler A,Zechner P,Aliberti S,Neumann R,Kroegel C,Hoyer H

更新日期：2012-10-01 00:00:00

abstract：:Exacerbations of sarcoidosis are common. In particular, exacerbations of pulmonary sarcoidosis are reported in more than one-third of patients. Despite their frequent occurrence, there is little medical evidence concerning the definition, diagnosis, and treatment of pulmonary exacerbations of sarcoidosis. In this arti...

journal_title：Chest

authors： Panselinas E,Judson MA

更新日期：2012-10-01 00:00:00

abstract：:About one-third of the world population has latent TB infection (LTBI), the majority of which is distributed in 22 high-burden countries. Early diagnosis and treatment of active TB remains the top priority in resource-poor countries with high TB prevalence. Notwithstanding, because LTBI contributes significantly to th...

journal_title：Chest

authors： Sharma SK,Mohanan S,Sharma A

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (EBUS-TBNA) is performed with a dedicated 22- or 21-gauge needle while suction is applied. Fine-needle sampling without suction (capillary sampling) has been studied for endoscopic ultrasound and for biopsies at various body sites and ha...

journal_title：Chest

authors： Casal RF,Staerkel GA,Ost D,Almeida FA,Uzbeck MH,Eapen GA,Jimenez CA,Nogueras-Gonzalez GM,Sarkiss M,Morice RC

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:The implementation of workplace smoking bans has contributed to a significant reduction in the incidence of acute coronary syndrome admissions, but their influence on adult acute pulmonary disease admissions is unclear. We sought to assess the impact of a national smoking ban on nationwide admissions of indi...

journal_title：Chest

authors： Kent BD,Sulaiman I,Nicholson TT,Lane SJ,Moloney ED

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Patients with malignant pleural effusion (MPE) have limited prognoses. They require long-lasting symptom relief with minimal hospitalization. Indwelling pleural catheters (IPCs) and talc pleurodesis are approved treatments for MPE. Establishing the implications of IPC and talc pleurodesis on subsequent hospi...

journal_title：Chest

authors： Fysh ETH,Waterer GW,Kendall PA,Bremner PR,Dina S,Geelhoed E,McCarney K,Morey S,Millward M,Musk AWB,Lee YCG

更新日期：2012-08-01 00:00:00

abstract：:Measurement of lung volumes is an integral part of complete pulmonary function testing. Some lung volumes can be measured during spirometry; however, measurement of the residual volume (RV), functional residual capacity (FRC), and total lung capacity (TLC) requires special techniques. FRC is typically measured by one ...

journal_title：Chest

authors： Flesch JD,Dine CJ

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:In response to the Agency for Healthcare Research and Quality statement questioning the usefulness of “screening spirometry,” the National Heart, Lung, and Blood Institute and the COPD Foundation held a consensus conference in June 2008 to establish a procedure to detect cases of COPD in the general populati...

journal_title：Chest

authors： Nelson SB,LaVange LM,Nie Y,Walsh JW,Enright PL,Martinez FJ,Mannino DM,Thomashow BM

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:The World Trade Center (WTC) collapse on September 11, 2001, produced airflow obstruction in a majority of firefighters receiving subspecialty pulmonary evaluation (SPE) within 6.5 years post-September 11, 2001. METHODS:In a cohort of 801 never smokers with normal pre-September 11, 2001, FEV1, we correlated...

journal_title：Chest

authors： Nolan A,Naveed B,Comfort AL,Ferrier N,Hall CB,Kwon S,Kasturiarachchi KJ,Cohen HW,Zeig-Owens R,Glaser MS,Webber MP,Aldrich TK,Rom WN,Kelly K,Prezant DJ,Weiden MD

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:The epigenetic basis for human asthma is not well studied, particularly among older adults. This study investigated the methylation profiles in sputum DNA among older adults with asthma, using a population of smokers. METHODS:This was a cross-sectional study using the Lovelace Smokers Cohort, a population of...

journal_title：Chest

authors： Sood A,Petersen H,Blanchette CM,Meek P,Picchi MA,Belinsky SA,Tesfaigzi Y

更新日期：2012-08-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and usually fatal disease, based on a multifaceted and incompletely understood pathogenesis. Some of the cellular and molecular mechanisms of vascular remodeling have been experimentally explored, and it is obvious that alterations of microvessels are invo...

journal_title：Chest

authors： Hanumegowda C,Farkas L,Kolb M

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:The tumor microenvironment, of which cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs) are the major cellular components, plays an important role in tumor progression. This study evaluated the significance of podoplanin-positive CAFs and CD204-positive TAMs, which may reflect tumor...

journal_title：Chest

authors： Ito M,Ishii G,Nagai K,Maeda R,Nakano Y,Ochiai A

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:There is no consensus at the present time about the effect of welding on lung function decline. This study compared lung function decline between blue-collar workers exposed and not exposed to welding fumes in a French longitudinal cohort of 21,238 subjects aged 37 to 52 years at inclusion. METHODS:Medical ...

journal_title：Chest

authors： Thaon I,Demange V,Herin F,Touranchet A,Paris C

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Periodic leg movements (PLMs) may appear during nasal CPAP titration, persisting despite the elimination of hypopneas. METHODS:Systematic recordings of expiratory abdominal muscles on the right and left sides with surface electromyographic (EMG) electrodes lateral to navel, and close from the lateral side o...

journal_title：Chest

authors： Seo WH,Guilleminault C

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:The clinical manifestations of bronchial remodeling in asthma and the potential impact of this process on lung function remain unclear. We aimed to determine whether the presence of pathologic features of airway remodeling in patients with asthma was associated with steroid responsiveness in the short term. ...

journal_title：Chest

authors： Bourdin A,Kleis S,Chakra M,Vachier I,Paganin F,Godard P,Chanez P

更新日期：2012-06-01 00:00:00

abstract：:Identifying patients with impaired renal function is crucial in the setting of critical illness. Serum creatinine serves as the gold standard for assessing steady-state renal function, helping to define those with chronic kidney disease (CKD). Although these baseline creatinine values are often not available in the se...

journal_title：Chest

authors： Koyner JL

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Little is known about the association between left ventricular (LV) diastolic dysfunction and outcomes in patients with idiopathic or heritable pulmonary arterial hypertension (PAH). Our rationale was to investigate the prevalence of LV diastolic dysfunction, and its association with disease severity and out...

journal_title：Chest

authors： Tonelli AR,Plana JC,Heresi GA,Dweik RA

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:The accuracy of combined clinical examination (CE) and chest radiography (CXR) (CE + CXR) vs thoracic ultrasonography in the acute assessment of pneumothorax, hemothorax, and lung contusion in chest trauma patients is unknown. METHODS:We conducted a prospective, observational cohort study involving 119 adul...

journal_title：Chest

authors： Hyacinthe AC,Broux C,Francony G,Genty C,Bouzat P,Jacquot C,Albaladejo P,Ferretti GR,Bosson JL,Payen JF

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Acquired somatic mutations induced by oxidative stress may contribute to the molecular pathogenesis of chronic inflammatory airway diseases. The objective of this study was to assess the intensity of oxidative DNA damage and the presence of microsatellite DNA instability (MSI), a marker of acquired somatic m...

journal_title：Chest

authors： Tzortzaki EG,Dimakou K,Neofytou E,Tsikritsaki K,Samara K,Avgousti M,Amargianitakis V,Gousiou A,Menikou S,Siafakas NM

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Inadequate localized drug concentrations and systemic adverse effects are among the concerns when regional infections are treated with systemic antibiotics. We designed and fabricated a poly(D,L)-lactide-co-glycolide (PLGA)-based biodegradable drug delivery system and evaluated the release of antibiotics bot...

journal_title：Chest

authors： Liu KS,Liu SJ,Chen HY,Huang YK,Peng YJ,Wu RC,Ueng SW

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Schistosomiasis-associated pulmonary arterial hypertension (Sch-PAH) may be one of the most prevalent forms of pulmonary arterial hypertension (PAH) worldwide. However, the clinical and hemodynamical response to specific PAH therapy in Sch-PAH is not known. METHODS:We retrospectively analyzed the charts of ...

journal_title：Chest

authors： Fernandes CJCS,Dias BA,Jardim CVP,Hovnanian A,Hoette S,Morinaga LK,Souza S,Suesada M,Breda AP,Souza R

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Interferon-γ release assays (IGRAs) have been incorporated into several national guidelines for latent TB infection (LTBI) diagnosis. However, their optimal application is still controversial and evolving. The aim of this study is to evaluate the performance of confirmatory IGRAs in addition to tuberculin sk...

journal_title：Chest

authors： Song S,Jeon D,Kim JW,Kim YD,Kim SP,Cho JS,Lee SE,Cho WH,Park HK,Kim YS,Lee MK,Lee JH

更新日期：2012-04-01 00:00:00

abstract：:It is estimated that 350,000 people suffer a cardiac arrest each year in the United States, with one-half occurring out-of-hospital and the other half in-hospital. Overall survival is < 10% and has not changed significantly for decades. CPR is the umbrella term for attempts to restore organized cardiac contractility a...

journal_title：Chest

authors： Gaieski DF,Abella BS,Goyal M

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:The aim of this study was to characterize the practice of routinely obtaining tracheal aspirate cultures in children with tracheostomy tubes and to analyze the appropriateness of using this information to guide antibiotic selection for treatment of subsequent lower respiratory infections. METHODS:Pediatric ...

journal_title：Chest

authors： Cline JM,Woods CR,Ervin SE,Rubin BK,Kirse DJ

更新日期：2012-03-01 00:00:00